I wish to express my disappointment with the awarding of the Nobel Prize for physiology or medicine to Dr. Robert Edwards, a pioneer of in-vitro fertilization. In-vitro fertilization is an evil - not a good - that has been unleashed upon mankind. IVF is an artificial method of reproduction in which human embryos are produced in a laboratory where they are observed and manipulated. Here, a relationship of domination of researchers over their embryonic subjects exists which not only opens the door to new threats against life but is contrary to the dignity and equality that must be common to parents and children. Science is in fact now discovering that the process of IVF can cause genetic defects, which negatively alter the basic genetic constitution of the person and all of his or her future offspring. In addition, when an IVF baby is born, the child will never grow to know how many of his or her siblings or other embryos, were created and murdered in the development of the procedure. Since the birth of the first IVF child over thirty years ago, well over two million embryos have been discarded, or frozen, or selectively aborted, or miscarried or used in destructive experiments. We would all do well to remember that we too were once human embryos. Human beings are not raw materials to be exploited or commodities that can be bought and sold. To suggest otherwise is to endorse a macabre interpretation of progress. Pure and simple IVF is nothing more than Frankenstein science. PAUL KOKOSKI, Canada, October 9.